RPL10 Antibody

Background:

Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a ribosomalprotein that is a component of the 60S subunit. The protein belongsto the L10E family of ribosomal proteins. It is located in thecytoplasm. In vitro studies have shown that the chicken protein canbind to c-Jun and can repress c-Jun-mediated transcriptionalactivation, but these activities have not been demonstrated invivo. This gene was initially identified as a candidate for a Wilmstumor suppressor gene, but later studies determined that this geneis not involved in the suppression of Wilms tumor. This gene hasbeen referred to as 'laminin receptor homolog' because a chimerictranscript consisting of sequence from this gene and sequence fromthe laminin receptor gene was isolated; however, it is not believedthat this gene encodes a laminin receptor. Transcript variantsutilizing alternative polyA signals exist. The variant with thelongest 3' UTR overlaps the deoxyribonuclease I-like 1 gene on theopposite strand. This gene is co-transcribed with the smallnucleolar RNA gene U70, which is located in its fifth intron. As istypical for genes encoding ribosomal proteins, there are multipleprocessed pseudogenes of this gene dispersed through the genome.