RPL22 Antibody

Background:

Ribosomes, the organelles that catalyze protein synthesis,consist of a small 40S subunit and a large 60S subunit. Togetherthese subunits are composed of 4 RNA species and approximately 80structurally distinct proteins. This gene encodes a cytoplasmicribosomal protein that is a component of the 60S subunit. Theprotein belongs to the L22E family of ribosomal proteins. Itsinitiating methionine residue is post-translationally removed. Theprotein can bind specifically to Epstein-Barr virus-encoded RNAs(EBERs) 1 and 2. The mouse protein has been shown to be capable ofbinding to heparin. Transcript variants utilizing alternative polyAsignals exist. As is typical for genes encoding ribosomal proteins,there are multiple processed pseudogenes of this gene dispersedthrough the genome. It was previously thought that this gene mappedto 3q26 and that it was fused to the acute myeloid leukemia 1(AML1) gene located at 21q22 in some therapy-relatedmyelodysplastic syndrome patients with 3;21 translocations;however, these fusions actually involve a ribosomal protein L22pseudogene located at 3q26, and this gene actually maps to1p36.3-p36.2.