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Western blot analysis of RRAS2 in Jurkat cell lysate with RRAS2 antibody at (A) 1 and (B) 2 μg/mL
Western blot analysis of RRAS2 in Jurkat cell lysate with RRAS2 antibody at (A) 1 and (B) 2 μg/mL
Trial Size

RRAS2 Antibody

CATALOG NUMBER: 7249

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
Rabbit polyclonal RRAS2 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human RRAS2.
The immunogen is located within the last 50 amino acids of RRAS2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
RRAS2 antibody can be used for detection of RRAS2 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
Two isoforms of RRAS2 exists as a result of alternative splicing event.
Positive Control 1:
Cat. No. 1205 - Jurkat Cell Lysate
Predicted Molecular Weight:
22 kDa
Purification:
RRAS2 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
RRAS2 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
RRAS2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
RRAS2
Additional Names:
RRAS2 Antibody: TC21, TC21, Ras-related protein R-Ras2, Ras-like protein TC21
Protein Accession Number:
NP_036382
Protein Gi Number:
21361416
Ncbi Gene Id Number:
22800
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
RRAS2 Antibody: Activating mutations and overexpression of classical Ras subfamily members (K-RAS, N-RAS and H-RAS) have been widely investigated as key events in the development of human cancers. The RRAS subfamily of Ras-related proteins includes RRAS1, RRAS2 (TC21) and RRAS3 (M-Ras) show overall amino acid identity with the classical Ras subfamily (H-Ras, K-Ras and N-Ras) of 55–60%. RRAS2 is a small GTPbinding protein of the Ras superfamily of GTPases. It might transduce growth inhibitory signals across the cell membrane, exerting its effect through an effector shared with the Ras proteins. RRAS2 has high oncogenic potential and overexpression/mutations have been reported in several tumor tissues and cell lines.
Background Reference 1:
Ehrhardt A, Ehrhardt GR, Guo X, et al. Ras and relatives--job sharing and networking keep an old family together. Exp. Hematol. 2002; 30:1089-106.
Background Reference 2:
Lowe DG, Capon DJ, Delwart E, et al. Structure of the human and murine R-Ras genes, novel genes closely related to Ras proto-oncogenes. Cell 1987; 48:137-46
Background Reference 3:
Drivas GT, Shih A, Coutavas E, et al. Characterization of four novel Ras-like genes expressed in a human teratocarcinoma cell line. Mol. Cell. Biol. 1990;10:1793-8.
Background Reference 4:
Luo H, Hao X, Ge C, et al. TC21 promotes cell motility and metastasis by regulating the expression of E-cadherin and N-cadherin in hepatocellular carcinoma. Int. J. Oncol. 2010; 37:853-9

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7249

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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