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Western blot analysis in A549 cell line lysates (35ug/lane).
Western blot analysis in A549 cell line lysates (35ug/lane).

RRM1 Antibody

CATALOG NUMBER: 60-858

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
90 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
RRM1
Additional Names:
Ribonucleoside-diphosphate reductase large subunit, Ribonucleoside-diphosphate reductase subunit M1, Ribonucleotide reductase large subunit, RRM1, RR1
Protein Accession Number:
P23921
Protein Gi Number:
132608
Ncbi Gene Id Number:
6240
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes one of two non-identical subunits thatconstitute ribonucleoside-diphosphate reductase, an enzymeessential for the production of deoxyribonucleotides prior to DNAsynthesis in S phase of dividing cells. It is one of several geneslocated in the imprinted gene domain of 11p15.5, an importanttumor-suppressor gene region. Alterations in this region have beenassociated with the Beckwith-Wiedemann syndrome, Wilms tumor,rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, andbreast cancer. This gene may play a role in malignancies anddisease that involve this region.
Background Reference 1:
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)
Background Reference 2:
Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Background Reference 3:
Vinolas, N., et al. Lung Cancer (2010) In press :
Background Reference 4:
Niida, H., et al. Genes Dev. 24(4):333-338(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-858

List Size:
400 ul

List Price:

$495.00

Datasheet
Shipping Info

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