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Antibody used in WB on Human Heart at 0.2-1 ug/ml.
Antibody used in WB on Hum. Fetal Lung at 1 ug/ml.
Antibody used in WB on K562 at 1:200.
Antibody used in WB on Human Heart at 0.2-1 ug/ml.

RUVBL1 Antibody

CATALOG NUMBER: 25-060

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human RUVBL1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
RUVBL1 antibody can be used for detection of RUVBL1 by ELISA at 1:312500. RUVBL1 antibody can be used for detection of RUVBL1 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Positive Control 1:
Cat. No. XBL-10407 - Fetal Heart Tissue Lysate
Predicted Molecular Weight:
50 kDa
Purification:
Antibody is purified by peptide affinity chromatography method.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Storage Conditions:
For short periods of storage (days) store at 4°C. For longer periods of storage, store RUVBL1 antibody at -20°C. As with any antibody avoid repeat freeze-thaw cycles.
Ncbi Official Symbol:
RUVBL1
Additional Names:
RUVBL1, ECP54, NMP238, Pontin52, RVB1, TIH1, TIP49, TIP49A, INO80H, PONTIN
Protein Accession Number:
NP_003698
Protein Gi Number:
4506753
Ncbi Gene Id Number:
8607
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
RUVBL1 possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. It is the component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex.
Background Reference 1:
Jha, S., (2008) Mol. Cell. Biol. 28 (8), 2690-2700.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

25-060

List Size:
100 ul

List Price:

$519.00

Datasheet
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