Ruxolitinib . phosphate salt

CATALOG NUMBER: 10-043

Specifications

Predicted Molecular Weight:

306.4 . 98.0

Formula:

C17H18N6 . H3O4P

Cas:

1092939-17-7

Solubility:

Soluble in DMSO (10mg/ml).

Inchi Key:

JFMWPOCYMYGEDM-XFULWGLBSA-N

Smiles:

N#CC[C@H](C1CCCC1)N(N=C2)C=C2C3=NC=NC4=C3C=CN4.OP(O)(O)=O

Identity:

Determined by 1H-NMR and MS.

Advanced Validation

Properties

Purity:

greater than or equal to 98% (HPLC)

physical-state:

Lyophilized

Storage Conditions:

Short Term Storage: +4C. Long Term Storage: -20C. Handling Advice: Keep cool and dry. Use/Stability: Stable for at least 2 years after receipt when stored at -20C.

Additional Info

Additional Names:

INCB018424; INC 424

Background

Background:

Water-soluble phosphate salt of Ruxolitinib. Antineoplastic, anti-inflammatory and immunomodulating agent. Orally bioavailable potent ATP mimetic that inhibits both JAK1 and JAK2 with IC50 values of 2.7 and 4.5nM, respectively and is less selective for JAK3 (IC50=322nM). Affects DC differentiation and function, leading to impaired T cell activation. Used in the treatment of myeloproliferative neoplasms and psoriasis. Anticancer agent. Shown to induce apoptosis and autophagy. Potent and selective inhibitor of HIV-1 replication and virus reactivation in vitro. It is investigated against the spread of the SARS-CoV-2 (COVID-19)

Citations

Set Contents

Disclaimer

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:

This product is for research use only.

CATALOG NUMBER:

10-043

List Size:

25 mg

List Price:

$243.00

Datasheet

Shipping Info

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