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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

SAFB Antibody

CATALOG NUMBER: 59-146

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This SAFB antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 65-94 amino acids from the N-terminal region of human SAFB.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
103 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SAFB
Additional Names:
Scaffold attachment factor B1, SAF-B, SAF-B1, HSP27 estrogen response element-TATA box-binding protein, HSP27 ERE-TATA-binding protein, SAFB, HAP, HET, SAFB1
Protein Accession Number:
Q15424
Protein Gi Number:
116242782
Ncbi Gene Id Number:
6294
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a DNA-binding protein that has highspecificity for scaffold or matrix attachment region DNA elements(S/MAR DNA). This protein is thought to be involved in attachingthe base of chromatin loops to the nuclear matrix but there isconflicting evidence as to whether this protein is a component ofchromatin or a nuclear matrix protein. Scaffold attachment factorsare a specific subset of nuclear matrix proteins (NMP) thatspecifically bind to S/MAR. This encoded protein is thought toserve as a molecular base to assemble a 'transcriptosome complex'in the vicinity of actively transcribed genes. It is involved inthe regulation of the heat shock protein 27 transcription and alsocan act as an estrogen receptor corepressor. This gene is acandidate gene for breast tumorigenesis.
Background Reference 1:
Hammerich-Hille, S., et al. Breast Cancer Res. Treat. 121(2):503-509(2010)
Background Reference 2:
Hammerich-Hille, S., et al. J. Biol. Chem. 285(6):3608-3616(2010)
Background Reference 3:
Tsianou, D., et al. FEBS J. 276(18):5212-5227(2009)
Background Reference 4:
Chen, H., et al. Endocrinology 150(5):2429-2435(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-146

List Size:
400 ul

List Price:

$495.00

Datasheet
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