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Western blot analysis in K562 cell line lysates (35ug/lane).
Western blot analysis in K562 cell line lysates (35ug/lane).

SAP18 Antibody

CATALOG NUMBER: 58-153

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SAP18 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 58-86 amino acids from the Central region of human SAP18.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
18 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SAP18
Additional Names:
Histone deacetylase complex subunit SAP18, 18 kDa Sin3-associated polypeptide, 2HOR0202, Cell growth-inhibiting gene 38 protein, Sin3-associated polypeptide p18, SAP18
Protein Accession Number:
O00422
Ncbi Gene Id Number:
10284
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Histone acetylation plays a key role in the regulation ofeukaryotic gene expression. Histone acetylation and deacetylationare catalyzed by multisubunit complexes. The protein encoded bythis gene is a component of the histone deacetylase complex, whichincludes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and otherpolypeptides. This protein directly interacts with SIN3 andenhances SIN3-mediated transcriptional repression when tethered tothe promoter. A pseudogene has been identified on chromosome 2.
Background Reference 1:
Sorin, M., et al. PLoS Pathog.(6), E1000463 (2009) :
Background Reference 2:
McCallum, S.A., et al. Biochemistry 45(39):11974-11982(2006)
Background Reference 3:
Joselin, A.P., et al. J. Biol. Chem. 281(18):12475-12484(2006)
Background Reference 4:
Schwerk, C., et al. Mol. Cell. Biol. 23(8):2981-2990(2003)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-153

List Size:
400 ul

List Price:

$495.00

Datasheet
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