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Western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).
SCN1B Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Flow cytometric analysis of Hela cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis.
Western blot analysis in mouse Neuro-2a cell line lysates (35ug/lane).

SCN1B Antibody

CATALOG NUMBER: 55-309

Clonality:
Polyclonal
Tested Applications:
Flow, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Rabbit, Rat
Immunogen:
This SCN1B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 63-90 amino acids from the N-terminal region of human SCN1B.
Conjugate:
Unconjugated
Tested Applications:
Flow, IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
For FACS starting dilution is: 1:10~50
Predicted Molecular Weight:
25 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SCN1B
Additional Names:
Sodium channel subunit beta-1, SCN1B
Protein Accession Number:
Q07699
Protein Gi Number:
1705868
Ncbi Gene Id Number:
6324
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Voltage-gated sodium channels are heteromeric proteinsthat function in the generation and propagation of actionpotentials in muscle and neuronal cells. They are composed of onealpha and two beta subunits, where the alpha subunit provideschannel activity and the beta-1 subunit modulates the kinetics ofchannel inactivation. SCN1B encodes a sodium channel beta-1subunit. Mutations in this gene result in generalized epilepsy withfebrile seizures plus, Brugada syndrome 5, and defects in cardiacconduction. Multiple transcript variants encoding differentisoforms have been found for this gene.
Background Reference 1:
Grover, S., et al. Pharmacogenomics 11(7):927-941(2010)
Background Reference 2:
Tan, B.H., et al. Heart Rhythm 7(6):771-778(2010)
Background Reference 3:
Casini, S., et al. Cardiovasc. Res. 85(4):691-700(2010)
Background Reference 4:
Ogawa, R., et al. IntClin Pharmacol Ther 48(2):109-119(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-309

List Size:
400 ul

List Price:

$495.00

Datasheet
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