SCP2 Antibody

Background:

This gene encodes two proteins: sterol carrier protein X(SCPx) and sterol carrier protein 2 (SCP2), as a result oftranscription initiation from 2 independently regulated promoters.The transcript initiated from the proximal promoter encodes thelonger SCPx protein, and the transcript initiated from the distalpromoter encodes the shorter SCP2 protein, with the 2 proteinssharing a common C-terminus. Evidence suggests that the SCPxprotein is a peroxisome-associated thiolase that is involved in theoxidation of branched chain fatty acids, while the SCP2 protein isthought to be an intracellular lipid transfer protein. This gene ishighly expressed in organs involved in lipid metabolism, and mayplay a role in Zellweger syndrome, in which cells are deficient inperoxisomes and have impaired bile acid synthesis. Alternativesplicing of this gene produces multiple transcript variants, someencoding different isoforms.