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Western blot analysis in CEM cell line lysates (35ug/lane).
SEC63 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human liver tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in CEM cell line lysates (35ug/lane).

SEC63 Antibody

CATALOG NUMBER: 56-867

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This SEC63 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 139-168 amino acids from the N-terminal region of human SEC63.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
88 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SEC63
Additional Names:
Translocation protein SEC63 homolog, SEC63, SEC63L
Protein Accession Number:
Q9UGP8
Protein Gi Number:
18203500
Ncbi Gene Id Number:
11231
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The Sec61 complex is the central component of the proteintranslocation apparatus of the endoplasmic reticulum (ER) membrane.The protein encoded by this gene and SEC62 protein are found to beassociated with ribosome-free SEC61 complex. It is speculated thatSec61-Sec62-Sec63 may perform post-translational proteintranslocation into the ER. The Sec61-Sec62-Sec63 complex might alsoperform the backward transport of ER proteins that are subject tothe ubiquitin-proteasome-dependent degradation pathway. The encodedprotein is an integral membrane protein located in the rough ER.
Background Reference 1:
Waanders, E., et al. Clin. Genet. 78(1):47-56(2010)
Background Reference 2:
van Keimpema, L., et al. Liver Int. (2010) In press :
Background Reference 3:
Waanders, E., et al. Histochem. Cell Biol. 129(3):301-310(2008)
Background Reference 4:
You, K.T., et al. PLoS Biol.(5), E109 (2007) :

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-867

List Size:
400 ul

List Price:

$495.00

Datasheet
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