SEMA6D Antibody

Background:

Semaphorins are a large family, including both secretedand membrane associated proteins, many of which have beenimplicated as inhibitors or chemorepellents in axon pathfinding,fasciculation and branching, and target selection. All semaphorinspossess a semaphorin (Sema) domain and a PSI domain (found inplexins, semaphorins and integrins) in the N-terminal extracellularportion. Additional sequence motifs C-terminal to the semaphorindomain allow classification into distinct subfamilies. Resultsdemonstrate that transmembrane semaphorins, like the secreted ones,can act as repulsive axon guidance cues. This gene encodes a class6 vertebrate transmembrane semaphorin that demonstrates alternativesplicing. Several transcript variants have been identified andexpression of the distinct encoded isoforms is thought to beregulated in a tissue- and development-dependent manner. [providedby RefSeq].