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Western blot analysis in HepG2 cell line lysates (35ug/lane).
Western blot analysis in HepG2 cell line lysates (35ug/lane).

SEPSECS Antibody

CATALOG NUMBER: 59-861

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This SEPSECS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 444-474 amino acids from the C-terminal region of human SEPSECS.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
56 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SEPSECS
Additional Names:
O-phosphoseryl-tRNA(Sec) selenium transferase, Liver-pancreas antigen, LP, SLA-p35, SLA/LP autoantigen, Selenocysteine synthase, Sec synthase, Selenocysteinyl-tRNA(Sec) synthase, Sep-tRNA:Sec-tRNA synthase, SepSecS, Soluble liver antigen, SLA, UGA suppressor tRNA-associated protein, tRNA(Ser/Sec)-associated antigenic protein, SEPSECS, TRNP48
Protein Accession Number:
Q9HD40
Protein Gi Number:
62287911
Ncbi Gene Id Number:
51091
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The 21st amino acid, selenocysteine (sec), is distinctfrom other amino acids because it lacks its own tRNA synthetase andis the only amino acid synthesized on its cognate tRNA. Synthesisof sec begins with acylation of tRNA(sec) (TRSP; MIM 165060) byseryl-tRNA synthetase (SARS; MIM 607529) to give ser-tRNA(sec),which is subsequently phosphorylated by O-phosphoseryl-tRNA kinase(PSTK; MIM 611310) to give O-phosphoseryl-tRNA(sec). SEPSECScatalyzes the final step of sec synthesis by convertingO-phosphoseryl-tRNA(sec) to selenocysteinyl-tRNA(sec) usingselenophosphate as the selenium donor (Palioura et al., 2009[PubMed 19608919]).
Background Reference 1:
Agamy, O., et al. Am. J. Hum. Genet. 87(4):538-544(2010)
Background Reference 2:
Hart, K., et al. Lung Cancer (2010) In press :
Background Reference 3:
Volkmann, M., et al. J. Autoimmun. 34(1):59-65(2010)
Background Reference 4:
Palioura, S., et al. Science 325(5938):321-325(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-861

List Size:
400 ul

List Price:

$495.00

Datasheet
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