SETD7 Antibody

CATALOG NUMBER: 30-476

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SETD7.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
SETD7 antibody can be used for detection of SETD7 by ELISA at 1:312500. SETD7 antibody can be used for detection of SETD7 by western blot at 5.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Positive Control 1:
Fetal Pancreas Lysate
Predicted Molecular Weight:
41 kDa
Purification:
Antibody is purified by protein A chromatography method.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Concentration:
batch dependent
Storage Conditions:
For short periods of storage (days) store at 4°C. For longer periods of storage, store SETD7 antibody at -20°C. As with any antibody avoid repeat freeze-thaw cycles.
Ncbi Official Symbol:
SETD7
Additional Names:
SETD7, FLJ21193, KIAA1717, KMT7, SET7, SET7/9, SET9
Protein Accession Number:
NP_085151
Protein Gi Number:
18139549
Ncbi Gene Id Number:
80854
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SETD7 is a histone methyltransferase that specifically monomethylates 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. It plays a central role in the transcriptional activation of genes such as collagenase or insulin. It is recruited by IPF1/PDX-1 to the insulin promoter, leading to activate transcription. It has also methyltransferase activity toward non-histone proteins such as p53/TP53, TAF10, and possibly TAF7 by recognizing and binding the [KR]-[STA]-K in substrate proteins.
Background Reference 1:
Subramanian, K., (2008) Mol. Cell 30 (3), 336-347.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

30-476

List Size:
100 ul

List Price:

$473.00

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