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Western blot analysis of SGSM1 in human cerebellum tissue lysate with SGSM1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of SGSM1 in human brain tissue with SGSM1 antibody at 20 μg/mL.
Western blot analysis of SGSM1 in human cerebellum tissue lysate with SGSM1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Trial Size

SGSM1 Antibody

CATALOG NUMBER: 7033

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
SGSM1 antibody was raised against a 17 amino acid synthetic peptide near the center of human SGSM1.
The immunogen is located within amino acids 480 - 530 of SGSM1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
SGSM1 antibody can be used for detection of SGSM1 by Western blot at 1 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
At least four isoforms of SGSM1 are known to exist; SGSM1 antibody will detect all four isoforms.
Positive Control 1:
Cat. No. 1362 - Human Cerebellum Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Predicted Molecular Weight:
126 kDa
Purification:
SGSM1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SGSM1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SGSM1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SGSM1
Additional Names:
SGSM1 Antibody: RUTBC2, KIAA1941, RUTBC2, Small G protein signaling modulator 1, RUN and TBC1 domain-containing protein 2
Protein Accession Number:
NP_001035037
Protein Gi Number:
90577167
Ncbi Gene Id Number:
129049
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SGSM1 Antibody: Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM1 (RUTBC2) is a 1,148 amino acid protein that localizes to the Golgi apparatus and is mainly expressed in the CNS. SGSM1 interacts with RAP and RAB subfamily members of the small G proteins, and function as modulators of RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways.
Background Reference 1:
Bar-Sagi D and Hall A. Ras and Rho GTPases: a family reunion. Cell 2000; 103:227-38.
Background Reference 2:
Colicelli J. Human ras superfamily proteins and related GTPases. Sci. STKE 2004; 250:RE13.
Background Reference 3:
Yang H, Sasaki T, Minoshima S, et al. Identification of three novel proteins (SGSM1, 2, 3) which modulate small G protein (RAP and RAB)-mediated signaling pathway. Genomics 2007; 90:249-60.
Background Reference 4:
Williams JA, Chen X and Sabbatini ME. Small G proteins as key regulators of pancreatic digestive enzyme secretion. Am. J. Physiol. Endocrinol. Metab. 2009; 296:E405-14.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7033

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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$65 Standard Overnight flat rate for as many products shipped within the United States.

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