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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

SH2D1A Antibody

CATALOG NUMBER: 60-808

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This SH2D1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 85-114 amino acids from the C-terminal region of human SH2D1A.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
14 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SH2D1A
Additional Names:
SH2 domain-containing protein 1A, Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP, SH2D1A, DSHP, SAP
Protein Accession Number:
O60880
Ncbi Gene Id Number:
4068
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene encodes a protein that plays a major role in thebidirectional stimulation of T and B cells. This protein containsan SH2 domain and a short tail. It associates with the signalinglymphocyte-activation molecule, thereby acting as an inhibitor ofthis transmembrane protein by blocking the recruitment of theSH2-domain-containing signal-transduction molecule SHP-2 to itsdocking site. This protein can also bind to other related surfacemolecules that are expressed on activated T, B and NK cells,thereby modifying signal transduction pathways in these cells.Mutations in this gene cause lymphoproliferative syndrome X-linkedtype 1 or Duncan disease, a rare immunodeficiency characterized byextreme susceptibility to infection with Epstein-Barr virus, withsymptoms including severe mononucleosis and malignant lymphoma.Multiple transcript variants encoding different isoforms have beenfound for this gene.
Background Reference 1:
Ameratunga, R., et al. N. Z. Med. J. 122(1304):46-53(2009)
Background Reference 2:
Snow, A.L., et al. J. Clin. Invest. 119(10):2976-2989(2009)
Background Reference 3:
Nagy, N., et al. Proc. Natl. Acad. Sci. U.S.A. 106(29):11966-11971(2009)
Background Reference 4:
Ostrakhovitch, E.A., et al. Cell. Signal. 21(4):540-550(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

60-808

List Size:
400 ul

List Price:

$495.00

Datasheet
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