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Western blot analysis in human placenta tissue lysates (35ug/lane).
Western blot analysis in human placenta tissue lysates (35ug/lane).

SIAH1 Antibody

CATALOG NUMBER: 58-452

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This SIAH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 92-120 amino acids from the Central region of human SIAH1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
31 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SIAH1
Additional Names:
E3 ubiquitin-protein ligase SIAH1, 632-, Seven in absentia homolog 1, Siah-1, Siah-1a, SIAH1, HUMSIAH
Protein Accession Number:
Q8IUQ4
Protein Gi Number:
46577493
Ncbi Gene Id Number:
6477
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SIAH1 is a protein that is a member of the sevenin absentia homolog (SIAH) family. The protein is an E3 ligase andis involved in ubiquitination and proteasome-mediated degradationof specific proteins. The activity of this ubiquitin ligase hasbeen implicated in the development of certain forms of Parkinson'sdisease, the regulation of the cellular response to hypoxia andinduction of apoptosis. Alternative splicing results in severaladditional transcript variants, some encoding different isoformsand others that have not been fully characterized. [provided byRefSeq].
Background Reference 1:
Wu, H., et al. Biochem. Biophys. Res. Commun. 397(3):391-396(2010)
Background Reference 2:
Wen, Y.Y., et al. Mol. Carcinog. 49(5):440-449(2010)
Background Reference 3:
Dimitrova, Y.N., et al. J. Biol. Chem. 285(18):13507-13516(2010)
Background Reference 4:
Bruzzoni-Giovanelli, H., et al. J. Exp. Clin. Cancer Res. 29, 10 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-452

List Size:
400 ul

List Price:

$495.00

Datasheet
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