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Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).

SIGLEC5 Antibody

CATALOG NUMBER: 58-622

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This SIGLEC5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-132 amino acids from the N-terminal region of human SIGLEC5.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
61 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SIGLEC5
Additional Names:
Sialic acid-binding Ig-like lectin 5, Siglec-5, CD33 antigen-like 2, Obesity-binding protein 2, OB-BP2, OB-binding protein 2, CD170, SIGLEC5, CD33L2, OBBP2
Protein Accession Number:
O15389
Ncbi Gene Id Number:
8778
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
The sialic acid-binding immunoglobulin-like lectins(SIGLECs), such as SIGLEC5, are a subgroup of the immunoglobulin(Ig) superfamily that mediate protein-carbohydrate interactions.They specifically interact with sialic acids in glycoproteins andglycolipids, with each SIGLEC having a particular preference forboth the nature of the sialic acid and its glycosidic linkage toadjacent sugars. SIGLECs have similar structures, includingextracellular Ig-like domains composed of an N-terminal V-setdomain followed by varying numbers of C2-set domains. It appearsthat all SIGLECs have an unusual arrangement of conserved cysteineresidues in the V-set and adjacent C2-set domains. Most SIGLECs areexpressed uniquely within the hematopoietic system (Cornish et al.,1998 [PubMed 9731071]).
Background Reference 1:
Soto, P.C., et al. J. Immunol. 184(8):4185-4195(2010)
Background Reference 2:
Davila, S., et al. Genes Immun. 11(3):232-238(2010)
Background Reference 3:
Carlin, A.F., et al. J. Exp. Med. 206(8):1691-1699(2009)
Background Reference 4:
Zhuravleva, M.A., et al. J. Mol. Biol. 375(2):437-447(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-622

List Size:
400 ul

List Price:

$495.00

Datasheet
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