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Western blot analysis of extracts from JK tissue using SirT1 (Phospho-Ser47) Antibody. The lane on the right is treated with the antigen-specific peptide.
Western blot analysis of extracts from JK tissue using SirT1 (Phospho-Ser47) Antibody. The lane on the right is treated with the antigen-specific peptide.

SirT1 (phospho Ser47) Antibody

CATALOG NUMBER: 79-978

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
SirT1 (phospho Ser47) antibody was raised against a peptide sequence around phosphorylation site of serine 47 (E-R-S (p)-P-G) derived from Human SirT1.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
The antibody detects endogenous level of SirT1 only when phosphorylated at serine 47.
Predicted Molecular Weight:
110 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Clonality:
Polyclonal
Isotype:
IgG
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
SIRT1
Additional Names:
hSIR2, hSIRT1, NAD-dependent deacetylase sirtuin 1, SIR1, SIR2L1
Protein Accession Number:
NP_001135970.1
Protein Gi Number:
7657575
Ncbi Gene Id Number:
23411
Background:
NAD-dependent protein deacetylase that links transcriptional regulation directly to intracellular energetics and participates in the coordination of several separated cellular functions such as cell cycle, response to DNA damage, metobolism, apoptosis and autophagy. Can modulate chromatin function through deacetylation of histones and can promote alterations in the methylation of histones and DNA, leading to transcriptional repression. Deacetylates a broad range of transcription factors and coregulators, thereby regulating target gene expression positively and negatively.
Background Reference 1:
Gao Z, et al. (2011) J Biol Chem 286, 22227-34. Zschoernig B, Mahlknecht U (2009)Biochem Biophys Res Commun 381, 372-7. Nasrin N, et al. (2009)PLoS One 4, e8414.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-978

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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