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The purity of rh CD244 / 2B4 / SLAMF4 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.
The purity of rh CD244 / 2B4 / SLAMF4 was determined by DTT-reduced (+) SDS-PAGE and staining overnight with Coomassie Blue.

SLAMF 4 Recombinant Protein

CATALOG NUMBER: 96-001

Tested Applications:
WB
Specifications
source-species:
HEK293 cells
Species:
Human
source-species:
HEK293 cells
Recombinant Protein Sequence:
Cys 22 - Arg 221
Fusion Tag:
His Tag
Tested Applications:
WB
Application Note:
This recombinant protein can be used for WB. For research use only.
Predicted Molecular Weight:
23.1 kDa
Biological Activity:
Measured by its binding ability in a functional ELISA. Immobilized rh CD244 / 2B4 at 2μg/ml (100μl/well) can bind human CD48. The EC50 of human CD48 is 0. 39μg/ml.
Purity:
>95% as determined by SDS-PAGE.
physical-state:
Lyophilized
Buffer:
PBS, pH7.4
Storage Conditions:
Lyophilized Protein should be stored at -20°C or lower for long term storage. Upon reconstitution, working aliquots should be stored at -20°C or -70°C. Avoid repeated freeze-thaw cycles.
Ncbi Official Symbol:
CD244
Additional Names:
CD244, 2B4, SLAMF4, NKR2B4, NAIL, h2B4
Protein Accession Number:
NP_057466
Ncbi Gene Id Number:
51744
Background:
Natural killer cell receptor 2B4 is also known as NK cell type I receptor protein 2B4 (NKR2B4 or h2B4), SLAM family member 4 (SLAMF4), Signaling lymphocytic activation molecule 4, CD antigen CD244. NKR2B4 / CD244 contains two Ig-like (immunoglobulin-like) domains. CD244 is expressed in spleen, PBL, followed by lung, liver, testis and small intestine. CD244 interacts with CD48. Following phosphorylation, CD244 is able to recruit PTPN11/SHP-2 and SH2D1A/SAP. SLAMF4 modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.
Background Reference 1:
Nakajima H., et al., 1999, Eur. J. Immunol. 29:1676-1683.
Background Reference 2:
Kubin M.Z., et al., 1999, Eur. J. Immunol. 29:3466-3477.
Background Reference 3:
Boles K.S., et al., 1999, Tissue Antigens 54:27-34.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Products are intended for laboratory research purposes only and should be used by qualified personnel only. They are not intended for use in humans. ProSci is not liable for damages or injuries resulting from receipt and/or use of ProSci materials. Please refer to the Material Safety Data Sheet (MSDS) for safe storage, handling, and use procedures.

CATALOG NUMBER:

96-001

List Size:
0.1 mg

List Price:

$540.00

Datasheet
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