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Western blot analysis of SLAMF1 in rat colon tissue lysate with SLAMF1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of SLAMF1 in human colon tissue with SLAMF1 antibody at 5 μg/mL.
Immunofluorescence of SLAMF1 in human colon tissue with SLAMF1 antibody at 20 μg/mL.
Western blot analysis of SLAMF1 in rat colon tissue lysate with SLAMF1 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

SLAMF1 Antibody

CATALOG NUMBER: 6247

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
SLAMF1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human SLAMF1.
The immunogen is located within amino acids 30 - 80 of SLAMF1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
SLAMF1 antibody can be used for detection of SLAMF1 by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
4 isoforms of SLAMF1 are known to exist; this antibody will is predicted to recognize all 4 isoforms. SLAMF1 antibody is predicted to not cross-react with other SLAM protein family members.
Positive Control 1:
Cat. No. 1472 - Rat Colon Tissue Lysate
Purification:
SLAMF1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SLAMF1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SLAMF1 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SLAMF1
Additional Names:
SLAMF1 Antibody: SLAM, CD150, CDw150, SLAM, Signaling lymphocytic activation molecule
Protein Accession Number:
NP_003028
Protein Gi Number:
4506969
Ncbi Gene Id Number:
6504
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SLAMF1 Antibody: The signaling lymphocyte-activation molecule family member 1 (SLAMF1) is a novel receptor on T cells that potentiates T cell expansion in a CD28-independent manner. SLAMF1 is predominantly expressed by hematopoietic tissues. Reports suggest that the extracellular domain of SLAMF1 is the receptor for the measles virus and acts as a co-activator on both T and B cells. It is thought to interact with SH2D1A and with PTPN11 via its cytoplasmic domain. Mutations of the SLAM associated gene may be associated with X-linked lympho-proliferative disease (XLP).
Background Reference 1:
Cocks BG, Chang CC, Carballido JM, et al. 1995. A novel receptor involved in T cell activation. Nature 1995; 376:260-3.
Background Reference 2:
Tatsuo H, Ono N, Tanaka K, et al. SLAM (CDw150) is a cellular receptor for measles virus. Nature 2000; 406:893-7.
Background Reference 3:
Aversa G, Chang CC, Carballido JM, et al. Engagement of the signaling lymphocytic activation molecule (SLAM) on activated T cells results in IL-2-independent, Cyclosporin A-sensitive T cell proliferation and IFN-α production. J. Immunol. 1997; 158:4036-44.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6247

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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