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Western blot analysis of SLAMF4 in Daudi cell lysate with SLAMF4 antibody at (A) 1 and (B) 2 μg/mL.
Immunofluorescence of SLAMF4 in Daudi cells with SLAMF4 antibody at 20 μg/mL.
Western blot analysis of SLAMF4 in Daudi cell lysate with SLAMF4 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

SLAMF4 Antibody

CATALOG NUMBER: 6253

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
SLAMF4 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human SLAMF4.
The immunogen is located within the last 50 amino acids of SLAMF4.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
SLAMF4 antibody can be used for detection of SLAMF4 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
At least three isoforms of SLAMF4 are known to exist. SLAMF4 antibody is predicted to not cross-react with other SLAM protein family members.
Positive Control 1:
Cat. No. 1224 - Daudi Cell Lysate
Purification:
SLAMF4 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SLAMF4 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SLAMF4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
CD244
Additional Names:
SLAMF4 Antibody: 2B4, NAIL, Nmrk, NKR2B4, SLAMF4, 2B4, Natural killer cell receptor 2B4, NK cell activation-inducing ligand
Protein Accession Number:
NP_1160135
Protein Gi Number:
7706529
Ncbi Gene Id Number:
51744
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SLAMF4 Antibody: The signaling lymphocyte-activation molecule family member 4 (SLAMF4), also known as 2B4, is an important regulator of Natural Killer (NK) cell activation. It is expressed on NK cells as well as on subsets of T cells and interacts with SLAMF2, causing the activation of both SLAMF4- and SLAMF2-expressing cells. Patients with systemic lupus erythmatosus have lower than normal levels of SLAMF4 expressed on their NK cells and monocytes, suggesting that SLAMF4 may play a role in this autoimmune disease.
Background Reference 1:
Claus M, Meinke S, Bhat R, et al. Regulation of NK cell activity by 2B4, NTB-A and CRACC. Front. Biosci. 2008; 13:956-65.
Background Reference 2:
Sidorenko SP and Clark EA. The dual-function CD150 receptor sub-family: the viral attraction. Nat. Immunol. 4:19-24.
Background Reference 3:
Assarsson E, Kambayashi T, Persson CM, et al. 2B4/CD48-mediated regulation of lymphocyte activation and function. J. Immunol. 2005; 175:2045-9
Background Reference 4:
Kim JR, Matther SO, Patel RK, et al. Altered expression of signalling lymphocyte activation molecule (SLAM) family receptors CS1 (CD319) and 2B4 (CD244) in patients with systemic lupus erythmatosus. Clin. Exp. Immunol. 2010; 160:348-58

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6253

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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