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Western blot analysis in HepG2 cell line lysates (35ug/lane).
SLC12A7 Antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human heart tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in HepG2 cell line lysates (35ug/lane).

SLC12A7 Antibody

CATALOG NUMBER: 56-393

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This SLC12A7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 89-117 amino acids from the N-terminal region of human SLC12A7.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:10~50
Predicted Molecular Weight:
119 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SLC12A7
Additional Names:
Solute carrier family 12 member 7, Electroneutral potassium-chloride cotransporter 4, K-Cl cotransporter 4, SLC12A7, KCC4
Protein Accession Number:
Q9Y666
Protein Gi Number:
166202480
Ncbi Gene Id Number:
10723
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SLC12A7 mediates electroneutral potassium-chloride cotransport when activated by cell swelling. May mediate K(+) uptake into Deiters' cells in the cochlea and contribute to K(+) recycling in the inner ear. Important for the survival of cochlear outer and inner hair cells and the maintenance of the organ of Corti. May be required for basolateral Cl(-) extrusion in the kidney and contribute to renal acidification (By similarity).
Background Reference 1:
Hartmann, A.M., et al. J. Biol. Chem. 285(31):23994-24002(2010)
Background Reference 2:
Kamatani, Y., et al. Nat. Genet. 42(3):210-215(2010)
Background Reference 3:
Chen, Y.F., et al. Cancer Res. 69(22):8585-8593(2009)
Background Reference 4:
Fujii, T., et al. J. Biol. Chem. 284(1):619-629(2009)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-393

List Size:
400 ul

List Price:

$495.00

Datasheet
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