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Western blot analysis of Slc35D1 inA-20 lysate with Slc35D1 antibody at (A) 1 and (B) 2 μg/mL.
Western blot analysis of Slc35D1 inA-20 lysate with Slc35D1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

Slc35D1 Antibody

CATALOG NUMBER: 4649

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Bovine: (88%), Pig: (81%)
Immunogen:
Slc35D1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human Slc35D1.
The immunogen is located within the first 50 amino acids of Slc35D1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
Slc35D1 antibody can be used for detection of Slc35D1 by Western blot at 1 - 2 μg/mL.
Antibody validated: Western Blot in mouse samples. All other applications and species not yet tested.
Specificity:
This antibody is predicted to not cross-react with the highly homologous Slc35D2.
Positive Control 1:
Cat. No. 1288 - A20 Cell Lysate
Purification:
Slc35D1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Slc35D1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Slc35D1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SLC35D1
Additional Names:
Slc35D1 Antibody: UGTREL7, KIAA0260, UGTREL7, Solute carrier family 35 member D1, UGTrel7
Protein Accession Number:
NP_055954
Protein Gi Number:
14028875
Ncbi Gene Id Number:
23169
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.
Background Reference 1:
Ishida N and Kawakita M. Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch.2004; 447:768-75.
Background Reference 2:
Muraoka M, Kawakita M, and Ishita N. Molecular characterization of human UDP-glucuronic acid/UDP-N-acetylgalactosamine transporter, a novel nucleotide sugar transporter with dual substrate specificity. FEBS Lett.2001; 495:87-93.
Background Reference 3:
Hiraoka S, Furuichi T, Nishimura G, et al. Nucleotide-sugar transporter Slc35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human. Nat. Med.2007; 13:1363-7.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4649

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

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