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Western blot analysis of SLC36A2 in human stomach tissue lysate with SLC36A2 antibody at1 μg/ml.
Western blot analysis of SLC36A2 in human stomach tissue lysate with SLC36A2 antibody at1 μg/ml.
Trial Size

SLC36A2 Antibody

CATALOG NUMBER: 8341

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
SLC36A2 antibody was raised against a 15 amino acid peptide near the amino terminus of human SLC36A2.
The immunogen is located within amino acids 30 - 80 of SLC36A2.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
SLC36A2 antibody can be used for detection of SLC36A2 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
SLC36A2 antibody is human specific. SLC36A2 is predicted to not cross-react with other members of the SLC36 protein family.
Positive Control 1:
Cat. No. 1319 - Human Stomach Tissue Lysate
Predicted Molecular Weight:
Predicted: 53 kDa
Observed: 52 kDa
Purification:
SLC36A2 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SLC36A2 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SLC36A2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
SLC36A2
Additional Names:
Solute carrier family 36 (proton/amino acid symporter) member 2, proton-coupled amino acid transporter 2, PAT2, TRAMD1
Protein Accession Number:
NP_861441
Protein Gi Number:
222418631
Ncbi Gene Id Number:
153201
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SLC36A2 is a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline (1,2). Both SLC36A2 and its paralog SLC36A1 are expressed in neurons, but SLC36A2 localizes to the endoplasmic reticulum and recycling endosome, while SLC36A1 is expressed in the lysosome (2). SLC36A2 is thought to contribute to neuronal transport and sequestration of amino acids such as glycine, alanine, and proline (2). Mutations in this gene are associated with iminoglycinuria and hyperglycinuria (3).
Background Reference 1:
Boll M, Foltz M, Rubio-Aliaga I, et al. Functional characterization of two novel mammalian electrogenic proton-dependent amino acid cotransporters. J. Biol. Chem. 2002; 277:22966-73.
Background Reference 2:
Rubio-Aliaga I, Boll M, Vogt Weisenhorn DM, et al. The proton/amino acid cotransporter PAT2 is expressed in neurons with a different subcellular localization than its paralog PAT1. J. Biol. Chem. 2004; 279:2754-60.
Background Reference 3:
Broer S, Bailey CG, Kowalczuk S, et al. Iminoglycinuria and hyperglycinuria are discrete human phenotypes resulting from complex mutations in proline and glycine transporters. J. Clin. Invest. 2008; 118:3881-92.

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8341

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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