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Western blot analysis of SLFN12 in SK-N-SH cell lysate with SLFN12 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Western blot analysis of SLFN12 in SK-N-SH cell lysate with SLFN12 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Trial Size

SLFN12 Antibody

CATALOG NUMBER: 5539

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
SLFN12 antibody was raised against a 12 amino acid synthetic peptide from near the carboxy terminus human SLFN12.
The immunogen is located within the last 50 amino acids of SLFN12.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
SLFN12 antibody can be used for detection of SLFN12 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Positive Control 1:
Cat. No. 1220 - SK-N-SH Cell Lysate
Purification:
SLFN12 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SLFN12 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SLFN12 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SLFN12
Additional Names:
SLFN12 Antibody: SLFN3, Schlafen family member 12
Protein Accession Number:
NP_060512
Protein Gi Number:
157388955
Ncbi Gene Id Number:
55106
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SLFN12 Antibody: Despite being first described several years ago, the roles of the Schlafen (SLFN) family of proteins remain largely unknown. The SLFN genes are preferentially expressed in lymphoid tissues and differentially regulated during thymocyte maturation. It is thought that many play roles in cell growth, hemopoietic cell differentiation, and T cell development and maturation. Most members contain at least one divergent AAA domain (AAA_4) that may play a role in ATP binding. Although also known as SLFN3, a Schlafen family member that may be a marker of T cell activation, human SLFN12 has relatively low homology to SLFN3 in other species. Loss of the SLFN12 gene due to deletion is associated with Kabuki syndrome, a multiple congenital anomaly syndrome, suggesting SLFN may play a role in this genetic condition.
Background Reference 1:
Schwarz DA, Katamaya CD, and Hedrick SM. Schlafen, a new family of growth regulatory genes that affect thymocyte development. Immunity1998; 9:657-68.
Background Reference 2:
Bustos O, Naik S, Ayers G, et al. Evolution of the Schlafen genes, a gene family associated with embryonic lethality, meiotic drive, immune processes and orthopoxvirus virulence. Gene2009; 447:1-11.
Background Reference 3:
Condamine T, Le Laduec J-B, Chiffoleau E, et al. Characterization of Schlafen-3 expression in effector and regulatory T cells. J. Leuk. Biol.2010; 87:1-6.
Background Reference 4:
Cusco I, del Campo M, Vilardell M, et al. Array-CGH in patients with Kabuki-like phenotype: Identification of two patients with complex rearrangements including 2q37 deletions and no other recurrent aberration. BMC Med. Gen.2008; 9:27.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

5539

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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