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Western blot analysis of Slitrk1 in human brain tissue lysate with Slitrk1 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of Slitrk1 in human brain tissue with Slitrk1 antibody at 2.5 μg/mL.
Immunofluorescence of slitrk1 in human brain tissue with slitrk1 antibody at 20 μg/mL.
Western blot analysis of Slitrk1 in human brain tissue lysate with Slitrk1 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

Slitrk1 Antibody

CATALOG NUMBER: 4453

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Slitrk1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human Slitrk1.
The immunogen is located within amino acids 630 - 680 of Slitrk1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
Slitrk1 antibody can be used for detection of Slitrk1 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Specificity:
This antibody is predicted to have no cross-reactivity to other Slitrk proteins.
Positive Control 1:
Cat. No. 1303 - Human Brain Tissue Lysate
Positive Control 2:
Cat. No. 10-301 - Human Brain Tissue Slide
Purification:
Slitrk1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
Slitrk1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
Slitrk1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SLITRK1
Additional Names:
Slitrk1 Antibody: TTM, LRRC12, KIAA1910, UNQ233/PRO266, SLIT and NTRK-like protein 1, Leucine-rich repeat-containing protein 12
Protein Accession Number:
NP_443142
Protein Gi Number:
40217817
Ncbi Gene Id Number:
114798
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Slitrk1 Antibody: SLIT and NTRK-like family 1 (Slitrk1) is a member a protein family consisting of six homologous transmembrane proteins (Slitrk1-6) that share two conserved leucine-rich repeat domains in the extracellular domain and have significant homology to Slit, a secreted axonal growth-controlling protein. These proteins are also homologous to trk neurotrophin receptors in their intracellular domains. Expression of Slitrk proteins is highly restricted to neural and brain tumor tissues, but varies within the family. For example, Slitrk1 is expressed primarily in mature neurons. Overexpression of Slitrk1 in transfected neuronal cells induced unipolar neurites, while expression of the other Slitrk proteins inhibited neurite outgrowth, suggesting that these proteins are involved in the control of neurite outgrowth. While Slitrk1 variants have been suggested associated with Tourette's Syndrome, it is thought to play only a minor role if at all.
Background Reference 1:
Aruga J and Mikoshiba K. Identification and characterization of Slitrk, a novel transmembrane protein family controlling neurite outgrowth. Mol. Cell Neurosci.2003; 24:117-29.
Background Reference 2:
Aruga J, Yokota N, and Mikoshiba K. Human SLITRK family genes: genomic organization and expression profiling in normal and brain tumor tissue. Gene2003; 315:87-94.
Background Reference 3:
Abelson JF, Kwan KY, O'Roak BJ, et al. Sequence variants in SLITRK1 are associated with Tourette's syndrome. Science2005; 310:317-20.
Background Reference 4:
Fabbrini G, Pasquini M, Aurilia C, et al. A large Italian family with Gilles de la Tourette syndrome: clinical study and analysis of the SLITRK1 gene. Mov. Disord.2007; 22:2229-34.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

4453

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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