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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in CEM cell line lysates (35ug/lane).

SMC1A Antibody

CATALOG NUMBER: 57-109

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SMC1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 307-336 amino acids from the N-terminal region of human SMC1A.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
143 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SMC1A
Additional Names:
Structural maintenance of chromosomes protein 1A, SMC protein 1A, SMC-1-alpha, SMC-1A, Sb18, SMC1A, DXS423E, KIAA0178, SB18, SMC1, SMC1L1
Protein Accession Number:
Q14683
Protein Gi Number:
29336622
Ncbi Gene Id Number:
8243
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Proper cohesion of sister chromatids is a prerequisite forthe correct segregation of chromosomes during cell division. Thecohesin multiprotein complex is required for sister chromatidcohesion. This complex is composed partly of two structuralmaintenance of chromosomes (SMC) proteins, SMC3 and either SMC1L2or the protein encoded by this gene. Most of the cohesin complexesdissociate from the chromosomes before mitosis, although thosecomplexes at the kinetochore remain. Therefore, the encoded proteinis thought to be an important part of functional kinetochores. Inaddition, this protein interacts with BRCA1 and is phosphorylatedby ATM, indicating a potential role for this protein in DNA repair.This gene, which belongs to the SMC gene family, is located in anarea of the X-chromosome that escapes X inactivation. [provided byRefSeq].
Background Reference 1:
Limongelli, G., et al. Am. J. Med. Genet.152A (8), 2127-2129 (2010) :
Background Reference 2:
Homme, C., et al. Oncol. Rep. 24(1):47-56(2010)
Background Reference 3:
Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :
Background Reference 4:
Wong, R.W. Cell Cycle 9(1):198-200(2010)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

57-109

List Size:
400 ul

List Price:

$495.00

Datasheet
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