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Western blot analysis in CEM cell line lysates (35ug/lane).
Western blot analysis in CEM cell line lysates (35ug/lane).

SMC3 Antibody

CATALOG NUMBER: 58-027

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse, Rat
Immunogen:
This SMC3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 402-430 amino acids from the Central region of human SMC3.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
142 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SMC3
Additional Names:
Structural maintenance of chromosomes protein 3, SMC protein 3, SMC-3, Basement membrane-associated chondroitin proteoglycan, Bamacan, Chondroitin sulfate proteoglycan 6, Chromosome-associated polypeptide, hCAP, SMC3, BAM, BMH, CSPG6, SMC3L1
Protein Accession Number:
Q9UQE7
Protein Gi Number:
29337005
Ncbi Gene Id Number:
9126
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
This gene belongs to the SMC3 subfamily of SMC proteins.The encoded protein occurs in certain cell types as either anintracellular, nuclear protein or a secreted protein. The nuclearform, known as structural maintenance of chromosomes 3, is acomponent of the multimeric cohesin complex that holds togethersister chromatids during mitosis, enabling proper chromosomesegregation. Post-translational modification of the encoded proteinby the addition of chondroitin sulfate chains gives rise to thesecreted proteoglycan bamacan, an abundant basement membraneprotein.
Background Reference 1:
Pie, J., et al. Am. J. Med. Genet.152A (4), 924-929 (2010) :
Background Reference 2:
Terret, M.E., et al. Nature 462(7270):231-234(2009)
Background Reference 3:
Revenkova, E., et al. Hum. Mol. Genet. 18(3):418-427(2009)
Background Reference 4:
Ridinger, H., et al. Exp. Mol. Pathol. 86(1):23-31(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-027

List Size:
400 ul

List Price:

$495.00

Datasheet
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