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Western blot analysis using SNCA monoclonal antibody against truncated SNCA recombinant protein.
Immunohistochemical analysis of paraffin - embedded human glioma tissue showing membrane location using SNCA antibody with DAB staining.
Western blot analysis using SNCA monoclonal antibody against truncated SNCA recombinant protein.

SNCA Antibody [2B2D1 / 2B2A11]

CATALOG NUMBER: 32-215

Clonality:
Monoclonal
Tested Applications:
ELISA, IHC, WB
Host Species:
Mouse
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Mouse
Species Reactivity:
Human
Immunogen:
Ni-NTA purified truncated recombinant SNCA expressed in E. Coli strain BL21 (DE3).
Conjugate:
Unconjugated
Tested Applications:
ELISA, IHC, WB
Application Note:
Western Blot:1:500 - 1:2,000
IHC(P):1:500 - 1:2,000
IHC(F):1:500 - 1:2,000
ELISA:Propose dilution 1:10,000
Determining optimal working dilutions by titration test.
Clonality:
Monoclonal
Buffer:
Ascitic fluid containing 0.03% sodium azide.
Concentration:
batch dependent
Storage Conditions:
SNCA monoclonal antibody can be stored at -20°C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SNCA
Additional Names:
NACP, PARK1, Non-A beta component of AD amyloid, NACP, PD1, PARK4
Protein Accession Number:
P37840
Protein Gi Number:
586067
Ncbi Gene Id Number:
6622
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Alpha-synuclein (SNCA), with 140-amino acid protein (about 15 kDa), belongs to the synuclein family, which also includes beta- and gamma-synuclein. SNCA is a soluble protein, expressed principally in the brain but also expressed in low concentrations in all tissues examined (except liver). SNCA is implicated in the regulation of dopamine release and transport. The triplication of the SNCA can cause Parkinson disease (PD) and diffuse Lewy body disease within the same kindred. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Immunohistochemistry for SNCA has become the histological technique of choice for the diagnosis for Parkinson's disease, Dementia with Lewy bodies and Multiple System Atrophy.
Background Reference 1:
J. Johnson, S. M. Hague, M. Hanson. Neurology, Aug 2004; 63: 554 – 556.
Background Reference 2:
Hong Tao Li, Xiao Jing Lin, Yuan Yuan Xie. Protein Pept Lett. 2006;13(4):385-90.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

32-215

List Size:
0.1 mL

List Price:

$432.00

Datasheet
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