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Western blot analysis in Hela cell line lysates (35ug/lane).
Western blot analysis in Hela cell line lysates (35ug/lane).

SOCS7 Antibody

CATALOG NUMBER: 58-953

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This SOCS7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 458-486 amino acids from the C-terminal region of human SOCS7.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
63 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SOCS7
Additional Names:
Suppressor of cytokine signaling 7, SOCS-7, Nck, Ash and phospholipase C gamma-binding protein, Nck-associated protein 4, NAP-4, SOCS7, NAP4, SOCS6
Protein Accession Number:
O14512
Ncbi Gene Id Number:
30837
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity).
Background Reference 1:
Pazienza, V., et al. J. Gen. Virol. 91 (PT 7), 1678-1686 (2010) :
Background Reference 2:
Sasi, W., et al. BMC Cancer 10, 178 (2010) :
Background Reference 3:
Kremer, B.E., et al. Cell 130(5):837-850(2007)
Background Reference 4:
Zody, M.C., et al. Nature 440(7087):1045-1049(2006)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-953

List Size:
400 ul

List Price:

$495.00

Datasheet
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