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Soluble TRAIL Receptor-1 Recombinant Protein

CATALOG NUMBER: 40-309

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
MSGTGAAAAT PSKVWGSSAG RIEPRGGGRG ALPTSMGQHG PSARARAGRA PGPRPAREAS PRLRVHKTFK FVVVGVLLQV VPSSAATIKL HDQSIGTQQW EHSPLGELCP PGSHRSERPG ACNRCTEGVG YTNASQQLFA CLPCTACKSD EEERSPCTTT RNTACQCKPG TFRNDNSAEM CRKCSTGCPR GMVKVKDCTP WSDIECVHKE SGNGHN
Biological Activity:
Biological activity was determined by its inhibitory effect of IL - 8 production in human PBMC by human sTRAIL/Apo2L. 95% inhibition (100 ng/mL of s TRAIL/Apo2L) was reached using a concentration of 100 ng/mL of sTRAIL Receptor - 1.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized Soluble TRAIL Receptor-1 recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted Soluble TRAIL Receptor-1 is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing Soluble TRAIL Receptor-1 recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
TNFRSF10A
Additional Names:
DR4, APO2, CD261, TRAILR1, TRAILR-1, DR4, Tumor necrosis factor receptor superfamily member 10A, Death receptor 4, TRAIL receptor 1
Protein Accession Number:
NP_003835.3
Protein Gi Number:
259906438
Ncbi Gene Id Number:
8797
Background:
TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-309

List Size:
0.01 mg, 0.05 mg

List Price:

Price range: $215.00 through $323.00

Datasheet
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