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Western blot analysis in Hela cell line lysates (35ug/lane).
Western blot analysis in Hela cell line lysates (35ug/lane).

SORD Antibody

CATALOG NUMBER: 58-227

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This SORD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-239 amino acids from the Central region of human SORD.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
38 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SORD
Additional Names:
Sorbitol dehydrogenase, L-iditol 2-dehydrogenase, SORD
Protein Accession Number:
Q00796
Protein Gi Number:
292495088
Ncbi Gene Id Number:
6652
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes theinterconversion of polyols and their corresponding ketoses, andtogether with aldose reductase (ALDR1; MIM 103880), makes up thesorbitol pathway that is believed to play an important role in thedevelopment of diabetic complications (summarized by Carr andMarkham, 1995 [PubMed 8535074]). The first reaction of the pathway(also called the polyol pathway) is the reduction of glucose tosorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizesthe sorbitol to fructose using NAD(+) cofactor.
Background Reference 1:
Szabo, Z., et al. Oncol. Rep. 23(5):1233-1239(2010)
Background Reference 2:
Johnatty, S.E., et al. PLoS Genet.(7), E1001016 (2010) :
Background Reference 3:
El-Kabbani, O., et al. Curr. Med. Chem. 11(4):465-476(2004)
Background Reference 4:
Pauly, T.A., et al. Structure 11(9):1071-1085(2003)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

58-227

List Size:
400 ul

List Price:

$495.00

Datasheet
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