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Western Blot at 1:500 dilution + human kidney lysate Lysates/proteins at 20 ug per lane.
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Western Blot at 1:500 dilution + human kidney lysate Lysates/proteins at 20 ug per lane.

SOST Antibody

CATALOG NUMBER: 59-168

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Homology:
Predicted species reactivity based on immunogen sequence: Bovine
Immunogen:
This SOST antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 38-66 amino acids from the N-terminal region of human SOST.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:500
Predicted Molecular Weight:
24 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SOST
Additional Names:
Sclerostin, SOST
Protein Accession Number:
Q9BQB4
Protein Gi Number:
20140220
Ncbi Gene Id Number:
50964
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Sclerostin is a secreted glycoprotein with a C-terminalcysteine knot-like (CTCK) domain and sequence similarity to the DAN(differential screening-selected gene aberrative in neuroblastoma)family of bone morphogenetic protein (BMP) antagonists.Loss-of-function mutations in this gene are associated with anautosomal-recessive disorder, sclerosteosis, which causesprogressive bone overgrowth. A deletion downstream of this gene,which causes reduced sclerostin expression, is associated with amilder form of the disorder called van Buchem disease. [provided byRefSeq].
Background Reference 1:
van Lierop, A.H., et al. Eur. J. Endocrinol. 163(5):833-837(2010)
Background Reference 2:
Liu, J.M., et al. J. Clin. Endocrinol. Metab. 95 (9), E112-E120 (2010) :
Background Reference 3:
Paternoster, L., et al. J. Clin. Endocrinol. Metab. 95(8):3940-3948(2010)
Background Reference 4:
Piters, E., et al. Hum. Mutat. 31 (7), E1526-E1543 (2010) :

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-168

List Size:
400 ul

List Price:

$495.00

Datasheet
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