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Western blot analysis of SOX10 in rat heart tissue lysate with SOX10 antibody at (A) 1 and (B) 2 μg/mL.
Immunohistochemistry of SOX10 in rat heart tissue with SOX10 Antibody at 5 μg/mL.
Immunofluorescence of SOX10 in rat heart tissue with SOX10 Antibody at 20 μg/mL.
Western blot analysis of SOX10 in rat heart tissue lysate with SOX10 antibody at (A) 1 and (B) 2 μg/mL.
Trial Size

SOX10 Antibody

CATALOG NUMBER: 8481

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Homology:
Predicted species reactivity based on immunogen sequence: Pig: (100%), Chicken: (89%), Goat: (100%)
Immunogen:
SOX10 antibody was raised against a peptide corresponding to 18 amino acids near the amino terminus of human SOX10.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
SOX10 antibody can be used for Western blot at 1 - 2 μg/mL. Antibody can also be used for Immunohistochemistry starting at 10 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in rat samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Specificity:
SOX10 Antibody is predicted to not cross-react with other SOX familiy members.
Positive Control 1:
Cat. No. 1461 - Rat Heart Tissue Lysate
Predicted Molecular Weight:
Predicted: 51 kDa
Observed: 54 kDa
Purification:
SOX10 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SOX10 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SOX10 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SOX10
Additional Names:
SOX10 Antibody: SRY (sex determining region Y)-box 10, DOM,WS4, PCWH, WS2E, WS4C
Protein Accession Number:
NP_008872
Protein Gi Number:
5902104
Ncbi Gene Id Number:
6663
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SOX10 Antibody: SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and the determination of the cell fate (1). The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins (2). This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development (2). Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschprung disease (3). SLC30A8 expression in beta-cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).
Background Reference 1:
Pusch C, Hustert E, Pfeifer D, et al. The SOX10/Sox10 gene from human and mouse: sequence, expression, and transactivation by the encoded HMG domain transcription factor. Hum. Genet. 1998; 103:115-23.
Background Reference 2:
Rehberg S, Lischka P, Glaser G, et al. Sox10 is an active nucleocytoplasmic shuttle protein, and shuttling is crucial for Sox10-mediated transactivation. Mol. Cell Biol. 2002; 22:5826-34.
Background Reference 3:
Pingault V, Bondurand N, Kuhlbrodt K, et al. SOX10 mutations in patients with Waardenburg-Hirschprung disease. Nat. Genet. 1998; 18:171-3.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8481

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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