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Western blot analysis of SOX17 in HepG2 cell lysate with SOX17 antibody at (A) 0.5 and (B) 1 μg/ml.
Immunofluorescence of SOX17 in mouse liver tissue with SOX17 antibody at 20 μg/ml.
Western blot analysis of SOX17 in HepG2 cell lysate with SOX17 antibody at (A) 0.5 and (B) 1 μg/ml.
Trial Size

SOX17 Antibody

CATALOG NUMBER: 7917

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
SOX17 antibody was raised against a 16 amino acid peptide near the center of human SOX17.
The immunogen is located within amino acids 240 - 290 of SOX17.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, WB
Application Note:
SOX17 antibody can be used for detection of SOX17 by Western blot at 0.5 - 1 μg/ml. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples and Immunofluorescence in mouse samples. All other applications and species not yet tested.
Specificity:
SOX17 antibody is human, mouse and rat reactive. SOX17 is predicted to not cross-react with other SOX proteins.
Positive Control 1:
Cat. No. 1211 - HepG2 Cell Lysate
Predicted Molecular Weight:
Predicted: 46 kDa
Observed: 42 kDa
Purification:
SOX17 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SOX17 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SOX17 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
SOX17
Additional Names:
SOX17 Antibody: VUR3, Transcription factor SOX-17
Protein Accession Number:
NP_071899
Protein Gi Number:
11967991
Ncbi Gene Id Number:
64321
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SOX17 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate (1,2). SOX17 is part of the SoxF subgroup which plays an important role in the differentiation of different cell types, including visceral and definitive endoderm and hematopoietic cell types (3,4). SOX17 is also essential for acquisition and maintenance of arterial identity (5).
Background Reference 1:
Kanai Y, Kanai-Azuma M, Noce T, et al. Identification of two Sox17 messenger RNA isoforms, with and without the high mobility group box region, and their differential expression in mouse spermatogenesis. J. Cell Biol. 1996; 133:667-81.
Background Reference 2:
Jiang T, Hou CC, She ZY, et al. The SOX gene family: function and regulation in testis determination and male fertility maintenance. Mol. Biol. Rep. 2013; 40:2187-94.
Background Reference 3:
Francois M, Koopman P, and Beltrame M. SoxF genes: key players in the development of the cardiovascular system. Int. J. Biochem. Cell Biol. 2010; 42:445-8.
Background Reference 4:
Kim I, Saunders TL, and Morrison SJ. Sox17 dependence distinguishes the transcriptional regulation of fetal from adult hematopoietic stem cells. Cell 2007; 130:470-83.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

7917

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

$65 Standard Overnight flat rate for as many products shipped within the United States.

$35 Dry Ice Shipment fee may be required on some items.

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