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Western blot analysis of SOX4 in human testis tissue lysate with SOX4 antibody at 1 μg/ml.
Immunohistochemistry of SOX4 in rat testis tissue with SOX4 antibody at 5 μg/mL.
Immunofluorescence of SOX4 in rat testis tissue with SOX4 antibody at 20 μg/mL.
Western blot analysis of SOX4 in human testis tissue lysate with SOX4 antibody at 1 μg/ml.
Trial Size

SOX4 Antibody

CATALOG NUMBER: 8123

Clonality:
Polyclonal
Tested Applications:
ELISA, IF, IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
SOX4 antibody was raised against a 16 amino acid peptide near the amino terminus of human SOX4.
The immunogen is located within the first 50 amino acids of SOX4.
Conjugate:
Unconjugated
Tested Applications:
ELISA, IF, IHC-P, WB
Application Note:
SOX4 antibody can be used for detection of SOX4 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.
Specificity:
SOX4 antibody is human, mouse and rat reactive.
Positive Control 1:
Cat. No. 1313 - Human Testis Tissue Lysate
Predicted Molecular Weight:
Predicted: 52 kDa
Observed: 520 kDa
Purification:
SOX4 antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SOX4 antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SOX4 antibody can be stored at 4°C up to one year. Antibodies should not be exposed to prolonged high temperatures
Ncbi Official Symbol:
SOX4
Additional Names:
SRY (Sex determining region Y)-box 4, Transcription factor SOX-4, EVI16
Protein Accession Number:
NP_003098
Protein Gi Number:
4507163
Ncbi Gene Id Number:
6659
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SOX4 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate (1,2). It may act as a transcriptional regulator after forming a protein complex with other proteins, such as syndecan binding protein (syntenin) (3). SOX4 contains one HMG box DNA-binding domain and may function in the apoptosis pathway leading to cell death. It has also been suggested to play a role in tumorigenesis and may mediate downstream effects of parathyroid hormone (PTH) and PTH-related protein (PTHrP) in bone development (4,5).
Background Reference 1:
Wotton D, Lake RA, Farr CJ, et al. The high mobility group transcription factor, SOX4, transactivates the human CD2 enhancer. J. Biol. Chem. 1995; 270:7515-22.
Background Reference 2:
Pan X, Li H, Zhang P, et al. Ubc9 interacts with SOX4 and represses its transcriptionalactivity. Biochem. Biophys. Res. Commun. 2006; 344:727-34.
Background Reference 3:
Castillo SD, Matheu A, Mariani N, et al. Novel transcriptional targets of the SRY-HMG box transcription factor SOX4 link its expression to the development of small cell lung cancer. Cancer Res. 2012; 72:176-86.
Background Reference 4:
Zhang H, Alberich-Jorda M, Amabile G, et al. Sox4 is a key oncogenic target in C/EBPa mutant acute myeloid leukemia. Cancer Cell 2013; 24:575-88.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8123

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
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