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Western blot analysis of lysed extracts from 3T3 cells treated with starvation using SP1 (Phospho-Thr739).
Western blot analysis of lysed extracts from 3T3 cells treated with starvation using SP1 (Phospho-Thr739).

SP1 (phospho Thr739) Antibody

CATALOG NUMBER: 79-481

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Immunogen:
SP1 (Phospho-Thr739) antibody was raised against a peptide sequence around phosphorylation site of threonine 739 (T-A-T (p) -P-S) derived from human SP1 .
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
Western Blot: 1:500~1:1000
Specificity:
This antibody detects endogenous levels of SP1 only when phosphorylated at threonine 739.
Predicted Molecular Weight:
90 kDa
Purification:
Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Clonality:
Polyclonal
Physical State:
Liquid
Buffer:
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Concentration:
1 mg/mL
Storage Conditions:
Store antibody at -20°C for up to one year.
Ncbi Official Symbol:
SP1
Additional Names:
TSFP1, TSFP1, Sp1 transcription factor
Protein Accession Number:
NP_612482.2
Protein Gi Number:
38372901
Ncbi Gene Id Number:
6667
Background:
Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression.
Background Reference 1:
Thiesen HJ, et al. (1990) Nucleic Acids Res. 18 (11): 3203-9. Zutter MM, et al. (1997) Blood. 90 (2): 678-89. Lou Z, et al. (2005) Cancer Res. 65 (3): 1007-17

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

79-481

List Size:
0.1 mg

List Price:

$376.00

Datasheet
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