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Western blot analysis in 293 cell line lysates (35ug/lane).
Western blot analysis in 293 cell line lysates (35ug/lane).

SRRT Antibody

CATALOG NUMBER: 59-057

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Bovine, Mouse
Immunogen:
This SRRT antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 54-81 amino acids from the N-terminal region of human SRRT.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
101 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SRRT
Additional Names:
Serrate RNA effector molecule homolog, Arsenite-resistance protein 2, SRRT, ARS2, ASR2
Protein Accession Number:
Q9BXP5
Protein Gi Number:
20137457
Ncbi Gene Id Number:
51593
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
SRRT acts as a mediator between the cap-binding complex (CBC) and the primary microRNAs (miRNAs) processing machinery during cell proliferation. Contributes to the stability and delivery of capped primary miRNA transcripts to the primary miRNA processing complex containing DGCR8 and RNASEN, thereby playing a role in RNA-mediated gene silencing (RNAi) by miRNAs. Binds capped RNAs (m7GpppG-capped RNA); however interaction is probably mediated via its interaction with NCBP1/CBP80 component of the CBC complex. Involved in cell cycle progression at S phase. Does not directly confer arsenite resistance but rather modulates arsenic sensitivity.
Background Reference 1:
Eijgelsheim, M., et al. Hum. Mol. Genet. 19(19):3885-3894(2010)
Background Reference 2:
Kiriyama, M., et al. Mol. Cell. Biol. 29(17):4729-4741(2009)
Background Reference 3:
Gruber, J.J., et al. Cell 138(2):328-339(2009)
Background Reference 4:
Wilson, M.D., et al. Mol. Cell. Biol. 28(5):1503-1514(2008)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

59-057

List Size:
400 ul

List Price:

$495.00

Datasheet
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