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Western blot of rat synaptic membrane (SPM) showing specific immunolabeling of the ~ 36k stargazin protein.
Western blot of rat synaptic membrane (SPM) showing specific immunolabeling of the ~ 36k stargazin protein.

Stargazin Antibody

CATALOG NUMBER: 50-182

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat stargazin, conjugated to keyhole limpet hemocyanin (KLH).
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
The antibody has been directly tested for reactivity in rat tissue. It is anticipated that the antibody will also work with mouse tissue based on the fact that this species has 100% homology with the amino acid sequence used as antigen.
Predicted Molecular Weight:
36
Purification:
Affinity Purified
Clonality:
Polyclonal
Physical State:
Liquid
Concentration:
batch dependent
Storage Conditions:
Stargazin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Cacng2
Protein Accession Number:
O88602
Protein Gi Number:
6685280
Ncbi Gene Id Number:
12300
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Stargazin is a member of the transmembrane AMPAR regulatory proteins (TARP) family and is involved in glutamate receptor trafficking. It has been recently demonstrated (Tomita et al., 2005; Priel et al., 2005) that the interaction between stargazin and AMPA receptors is critical for the correct localization of the receptors at the synapse. Phosphorylation of the stargazin protein at Thr 321 by Protein Kinase A regulates its interaction with PSD-95 and synaptic targeting of AMPA receptors (Choi et al., 2002).
Background Reference 1:
Tomita S, Adesnik H, Sekiguchi M, Zhang W, Wada K, Howe JR, Nicoll RA, Bredt DS,(2005) Stargazin modulates AMPA receptor gating and trafficking by distinct domains. Nature 435: 1052-1058.
Background Reference 2:
Priel A, Kolleker A, Ayalon G, Gillor M, Osten P, Stern-Bach Y. (2005) Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. J. Neurosci. 25, 2682–2686.
Background Reference 3:
Choi, J, Ko J, Park E, Lee JR, Yoon J, Lim S, Kim E, Phosphorylation of stargazin by protein kinase A regulates its interaction with PSD-95.J Biol Chem. 2002 Apr 5;277(14):12359-63.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-182

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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