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Antibody is used in Western blot to detect STK38 in SK-Br-3 (left) and Jurkat (right) cell line lysates.
Antibody is used in Western blot to detect STK38 in SK-Br-3 (left) and Jurkat (right) cell line lysates.

STK38 Antibody

CATALOG NUMBER: 62-638

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
This STK38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 410-439 amino acids from the C-terminal region of human STK38.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
54 kDa
Purification:
This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
STK38
Additional Names:
Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1, STK38 {ECO:0000312, EMBL:AAH120851}
Protein Accession Number:
Q15208
Protein Gi Number:
56749457
Ncbi Gene Id Number:
11329
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Stk38,also known as NUCLEAR DBF2-RELATED PROTEIN, contains 1 protein kinase domain that interacts with mob1 and mob2.The homodimeric s100b binds to two molecules of stk38. It is ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Stk38 activated by binding of s100b which releases autoinhibitory n-lobe interactions, enabling atp to bind and the autophosphorylation of ser-281. thr-444 then undergoes calcium- dependent phosphorylation by an upstream kinase. Interactions between phosphorylated thr-444 and the n-lobe promote additional structural changes that complete the activation of the kinase. Autoinhibition is also released by the binding of mob1/mobkl1a and mob2/hcca2 to the n-terminal of stk38.
Background Reference 1:
Devroe, E., et al., J. Biol. Chem. 279(23):24444-24451 (2004).
Background Reference 2:
Tamaskovic, R., et al., J. Biol. Chem. 278(9):6710-6718 (2003).
Background Reference 3:
Tripodis, N., et al., Genome Res. 8(6):631-643 (1998).
Background Reference 4:
Millward, T., et al., Proc. Natl. Acad. Sci. U.S.A. 92(11):5022-5026 (1995).

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

62-638

List Size:
400 ul

List Price:

$495.00

Datasheet
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