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Western blot analysis of STOX1 in human liver tissue lysate with STOX1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Western blot analysis of STOX1 in human liver tissue lysate with STOX1 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide.
Trial Size

STOX1 Antibody

CATALOG NUMBER: 6901

Clonality:
Polyclonal
Tested Applications:
ELISA, WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Immunogen:
STOX1 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human STOX1.
The immunogen is located within amino acids 870 - 920 of STOX1.
Conjugate:
Unconjugated
Tested Applications:
ELISA, WB
Application Note:
STOX1 antibody can be used for detection of STOX1 by Western blot at 1 μg/mL.
Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
Specificity:
STOX1 antibody is human reactive. At least three alternatively spliced transcript variants encoding distinct isoforms have been observed. STOX1 antibody recognize the two longest isoforms.
Positive Control 1:
Cat. No. 1304 - Human Liver Tissue Lysate
Purification:
STOX1 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
STOX1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
STOX1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
STOX1
Additional Names:
STOX1 Antibody: PEE4, C10orf24, Storkhead-box protein 1, Winged-helix domain-containing protein
Protein Accession Number:
NP_689922
Protein Gi Number:
63025200
Ncbi Gene Id Number:
219736
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
STOX1 Antibody: STOX1 (Storkhead box 1), also known as PEE4 or C10orf24, is a winged-helix domain containing transcription factor believed to play a role in the differentiation of stem cells. As a DNA-binding protein, STOX1 exists as three alternatively spliced isoforms, designated A, B and C, all of which localize to either the cytoplasm or the nucleus. Defects in STOX1 are the cause of pre-eclampsia/eclampsia 4 (PEE4), also known as gestational proteinuric hypertension. STOX1 was also found to be functionally involved in late-onset Alzheimer's disease.
Background Reference 1:
Van Dijk M, van Bezu J, Chim SS, et al. Maternal segregation of the Dutch preeclampsia locus at 10q22 with a new member of the winged helix gene family. Nat. Genet. 2005; 37:514-9.
Background Reference 2:
Kivinen K, Peterson H, Hiltunen L, et al. Evaluation of STOX1 as a preeclampsia candidate gene in a population-wide sample. Eur. J. Hum. Genet. 2007;15:494-7.
Background Reference 3:
Van Dijk M, van Bezu J, van Abel D, et al. The STOX1 genotype associated with pre-eclampsia leads to a reduction of trophoblast invasion by alpha-T-catenin upregulation. Hum Mol. Genet. 2010; 19:2658-67.
Background Reference 4:
Van Abel D, Hölzel DR, Jain S, et al. SFRS7-mediated splicing of tau exon 10 is directly regulated by STOX1A in glial cells. PLoS One 2011; 6 :e21994.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

6901

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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