SULF2 Antibody

CATALOG NUMBER: 56-647

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Human
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human
Homology:
Predicted species reactivity based on immunogen sequence: Mouse
Immunogen:
This SULF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 824-852 amino acids from the C-terminal region of human SULF2.
Conjugate:
Unconjugated
Tested Applications:
WB
Application Note:
For WB starting dilution is: 1:1000
Predicted Molecular Weight:
100 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SULF2
Additional Names:
Extracellular sulfatase Sulf-2, hSulf-2, 316-, SULF2, KIAA1247
Protein Accession Number:
Q8IWU5
Protein Gi Number:
33112446
Ncbi Gene Id Number:
55959
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Heparan sulfate proteoglycans (HSPGs) act as coreceptors for numerous heparin-binding growth factors and cytokines and are involved in cell signaling. Heparan sulfate 6-O-endosulfatases, such as SULF2, selectively remove 6-O-sulfate groups from heparan sulfate. This activity modulates the effects of heparan sulfate by altering binding sites for signaling molecules (Dai et al., 2005 [PubMed 16192265]).
Background Reference 1:
Lai, J.P., et al. Hepatology 52(5):1680-1689(2010) Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010) Lemjabbar-Alaoui, H., et al. Oncogene 29(5):635-646(2010) Tang, R., et al. J. Biol. Chem. 284(32):21505-21514(2009) Chau, B.N., et al. Cancer Res. 69(4):1368-1374(2009)

FOR RESEARCH USE ONLY

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Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

56-647

List Size:
400 ul

List Price:

$495.00

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