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Western blot analysis of SUSD3 in HeLa cell lysate with SUSD3 antibody at 1 μg/ml.
Immunocytochemistry of SUSD3 in 3T3 cells with SUSD3 antibody at 5 μg/ml.
Western blot analysis of SUSD3 in HeLa cell lysate with SUSD3 antibody at 1 μg/ml.
Trial Size

SUSD3 Antibody

CATALOG NUMBER: 8475

Clonality:
Polyclonal
Tested Applications:
ELISA, ICC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
SUSD3 antibody was raised against a 16 amino acid peptide from near the center of human SUSD3.
The immunogen is located within amino acids 120 - 170 of SUSD3.
Conjugate:
Unconjugated
Tested Applications:
ELISA, ICC, WB
Application Note:
SUSD3 antibody can be used for the detection of SUSD3 by Western blot at 1 - 2 μg/mL. Antibody can also be used for immunocytochemistry starting at 5 μg/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.
Specificity:
SUSD3 antibody is human and mouse reactive. Multiple isoforms of SUSD3 are known to exist.
Positive Control 1:
Cat. No. 1282 - 3T3 (NIH) Cell Lysate
Positive Control 2:
Cat. No. 17-201 - 3T3/BALB Cell Slide
Predicted Molecular Weight:
Predicted: 16, 22, 23, 28 kDa
Observed: 23 kDa
Purification:
SUSD3 Antibody is affinity chromatography purified via peptide column.
Clonality:
Polyclonal
Isotype:
IgG
physical-state:
Liquid
Buffer:
SUSD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration:
1 mg/mL
Storage Conditions:
SUSD3 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Ncbi Official Symbol:
SUSD3
Additional Names:
Sushi domain containing 3
Protein Accession Number:
NP_659443
Protein Gi Number:
21450717
Ncbi Gene Id Number:
203328
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Little is known of the function of the sushi domain containing 3 protein (SUSD3), but its expression has been reported in estrogen receptor-alpha (ERalpha)-positive breast tumors with decreased expression reported in aggressive malignant tumors (1,2). Recently, SUSD3 has been found to promote estrogen-dependent cell proliferation and may regulate cell-cell and cell-substrate interactions and migration in breast cancer (3). Furthermore, elevated SUSD3 mRNA levels were observed in aromatase inhibitor-responsive breast tumors, suggesting that it may also serve as a novel predictor of response to endocrine therapy and a potential therapeutic target (3).
Background Reference 1:
Abba MC, Hu Y, Sun H, et al. Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genomics 2005; 6:37.
Background Reference 2:
Parris TZ, Danielsson A, Nemes S, et al. Clinical implications of gene dosage and gene expression patterns in diploid breast cancer. Clin. Cancer Res. 2010; 16:3860-74.
Background Reference 3:
Moy I, Todorovic V, Dubash AD, et al. Estrogen-dependent sushi domain containing 3 regulates cytoskeleton organization and migration in breast cancer cells. Oncogene 2015; 34:323-33.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

8475

List Size:
0.02 mg, 0.1 mg

List Price:

Price range: $99.00 through $445.00

Datasheet
Shipping Info

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