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Synapsin I Antibody
Synapsin I Antibody

Synapsin I Antibody

CATALOG NUMBER: XPS-2029

Clonality:
Polyclonal
Tested Applications:
IF, IHC, IP, WB
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Rat
Immunogen:
Synapsin 1 polyclonal antibody was raised against synapsin I native protein purified from bovine brain.
Conjugate:
Unconjugated
Tested Applications:
IF, IHC, IP, WB
Application Note:
Synapsin I antibody can be used for strong and specific immunolabeling of the Synapsin I 78k doublet in Western blots of rat brain. Immunolabeling blocked by preadsorption of antibody with Synapsin. Applications include Dot Blots (DB), Western Blots (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) and Immunoprecipitation (IP). Human, mouse and rat have 100% amino acid sequence for Synapsin I. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB, 1:2000 for IHC and IF, and for IP 1 g will quantitatively immunoprecipitate all synapsin in 200 g rat brain.
Predicted Molecular Weight:
78
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Lyophilized
Concentration:
batch dependent
Storage Conditions:
For long term storage –80°C is recommended, but shorter term storage at –20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Ncbi Official Symbol:
SYN1
Protein Accession Number:
P17599
Protein Gi Number:
1351166
Ncbi Gene Id Number:
281510
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Synapsin I plays a key role in synaptic plasticity in brain. This effect is due in large part to the ability of the synapsins to regulate the availability of synaptic vesicles for release. In addition to its role in plasticity, the expression of synapsin I is a precise indicator of synapse formation. Thus synapsin I immunocytochemistry provides a valuable tool for the study of synaptogenesis. The role of synapsin in synaptic plasticity and in synaptogensis is regulated by phosphorylation.
Background Reference 1:
Stone, L.M., Browning M.D. and Finger T.E., "Differential distribution of the synapsins in the rat olfactory bulb," J. Neurosci. 14 (1994) 301 309.
Background Reference 2:
Jovanovic, J.N., Sihra, T.S., Nairn, A.C., Hemmings, H.C., Jr., Greengard, P., and Czernik, A.J., "Opposing changes in phosphorylation of specific sites in synapsin I during Ca2+-dependent glutamate release in isolated nerve terminals," J. Neurosci., 21 (2001) 7944-7953.
Background Reference 3:
Kao, H.T., Song, H.J., Porton, B., Ming, G.L., Hoh, J., Abraham, M., Czernik, A.J., Pieribone, V.A., Poo, M.M., and Greengard,P., "A protein kinase A-dependent molecular switch in synapsins regulates neurite outgrowth", Nature Neurosci., 5 (2002) 431 - 437.
Background Reference 4:
Nayak, A.C., Moore, C.I. and Browning, M.D., "CAM kinase II phosphorylation of the presynaptic protein synapsin is persistently increased during expression of long-term potentiation," Proc. Natl. Acad. Sci. (USA) 93 (1996) 15,451 -15,456.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

XPS-2029

List Size:
10 ug

List Price:

$540.00

Datasheet
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