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Western blot of rat hippocampal lysate showing specific labeling of the ~38k synaptophysin 2 protein.
Western blot of rat hippocampal lysate showing specific labeling of the ~38k synaptophysin 2 protein.

Synaptophysin Antibody

CATALOG NUMBER: 50-192

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Mouse, Rat
Immunogen:
Peptide corresponding to amino acid residues from the C-terminal region of rat synaptophysin 2, conjugated to keyhole limpet hemocyanin (KLH).
Conjugate:
Unconjugated
Tested Applications:
WB
Predicted Molecular Weight:
38
Purification:
Affinity Purified
Clonality:
Polyclonal
Physical State:
Liquid
Concentration:
batch dependent
Storage Conditions:
Synaptophysin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Synpr
Protein Accession Number:
P22831
Protein Gi Number:
33112632
Ncbi Gene Id Number:
66030
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Synaptophysin 2, also known as synaptoporin, is a component of the synaptic vesicle membrane and thought to play an important role in synaptic vesicle trafficking (Dai et al., 2003). It is highly homologous to synaptophysin 1, yet differs in expression. Whereas synaptophysin 1 is ubiquitiously expressed, synaptophysin 2 is concentrated in the mossy fiber synapses of the hippocampus (Grabs et al., 1994; Singec et al., 2002).
Background Reference 1:
Dai J, Ji C, Gu S, Wu Q, Wang L, Xu J, Zeng L, Ye X, Yin G, Xie Y, Mao Y (2003) Cloning and sequence analysis of the human cDNA encoding the synaptoporin, a highly conserved synaptic vesicle protein. Molecular Biology Reports 30:185-191.
Background Reference 2:
Singec I, Knoth R, Ditter M, Hagemeyer CE, Rosenbrock H, Frotscher M, Volk B (2002) Synaptic vesicle protein synaptoporin is differently expressed by subpopulations of mouse hippocampal neurons. J Comp Neurol 452(2):139-153.
Background Reference 3:
Grabs D, Bergmann M, Schuster T, Fox PA, Brich M, Gratz M (1994) Differential expression of synaptophysin and synaptoporin during pre- and postnatal development of the rat hippocampal network. Eur J Neurosci. 6(11): 1765-71..

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-192

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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