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Western blot of rat cortex lysate showing specific labeling of the ~65k synaptotagmin protein.
Western blot of rat cortex lysate showing specific labeling of the ~65k synaptotagmin protein.

Synaptotagmin Antibody

CATALOG NUMBER: 50-193

Clonality:
Polyclonal
Tested Applications:
WB
Host Species:
Rabbit
Species Reactivity:
Bovine, Chicken, Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Bovine, Chicken, Human, Mouse, Rat
Immunogen:
Synthetic peptide corresponding to amino acid residues within the synaptotagmin I protein.
Conjugate:
Unconjugated
Tested Applications:
WB
Predicted Molecular Weight:
65
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
Synaptotagmin antibody can be stored at -20°C and is stable at -20°C for at least 1 year.
Ncbi Official Symbol:
Syt1
Protein Accession Number:
P21707
Protein Gi Number:
94730428
Ncbi Gene Id Number:
25716
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Synaptotagmin 1 is a synaptic vesicle membrane glycoprotein that is widely expressed throughout the CNS and is generally thought to act as the Ca2+ sensor in the regulation of exocytosis and neurotransmitter release (Littleton and Bellen 1995). Recent studies indicate that synaptotagmin’s Ca2+ mediated binding of SNAP25 is essential for the Ca2+ dependent triggering of membrane fusion (Zhang et al., 2002). It has recently been demonstrated that discrete residues within the c(2)b binding domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size (Poskanzer et al., 2006).
Background Reference 1:
Littleton JT, Bellen HJ (1995) Synaptotagmin controls and modulates synaptic vesicle fusion in a Ca(2+) dependent manner. Trends Neurosci. Apr;18(4):177-83.
Background Reference 2:
Zhang X, Kim-Miller MJ, Fukuda M, Kowalchyk JA, Martin TF (2002) Ca2+ dependent synaptotagmin binding to SNAP25 is essential for Ca2+ triggered exocytosis. Neuron May 16;34(4):599-611.
Background Reference 3:
Poskanzer KE, Fetter RD, Davis GW (2006) Discrete residues in the c(2)b domain of synaptotagmin 1 independently specify endocytic rate and synaptic vesicle size. Neuron Apr 6;50(1):49-62.

FOR RESEARCH USE ONLY

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Disclaimer:
This product is for research use only.

CATALOG NUMBER:

50-193

List Size:
0.1 mL

List Price:

$540.00

Datasheet
Shipping Info

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