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Synaptotagmin (Phospho-Thr202) Antibody
Synaptotagmin (Phospho-Thr202) Antibody

Synaptotagmin (phospho Thr202) Antibody

CATALOG NUMBER: XPS-1027

Clonality:
Polyclonal
Tested Applications:
IHC, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse, Rat
Immunogen:
Synaptotagmin (Thr202) polyclonal antibody was raised against a synthetic phosphopeptide corresponding to amino acids residues surrounding the phospho Thr202 of synaptotagmin.
Conjugate:
Unconjugated
Tested Applications:
IHC, WB
Application Note:
Applications include Dot Blots (DB) and Western Blots (WB). Suitability for Immunohistochemistry (IHC) has not yet been determined. Human, mouse, and rat have 100% amino acid sequence identity with the antigen used to raise the antibody. When internally tested under ideal conditions the working dilutions were 1:1000 for DB and WB.
Specificity:
Synaptotagmin antibody is specific for Mr 60 - 62k synaptotagmin phosphorylated at Thr202.
Predicted Molecular Weight:
60/62
Purification:
Affinity Purified
Clonality:
Polyclonal
physical-state:
Liquid
Concentration:
batch dependent
Storage Conditions:
For long term storage –80°C is recommended, but shorter term storage at –20°C is also acceptable as aliquots may be taken without freeze/thawing due to the presence of 50% glycerol. Stable for one year.
Ncbi Official Symbol:
Syt1
Protein Accession Number:
P21707
Protein Gi Number:
94730428
Ncbi Gene Id Number:
25716
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Synaptotagmin is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis. Moreover recent studies indicate that the protein also plays a key role in endocytosis. Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin ability to influence both the exocytotic and endocytotic components of synaptic transmission.
Background Reference 1:
Poskanzer, K.E., Marek, K.W., Sweeney, S.T. and Davis, G.W., "Synaptotagmin I is necessary for compensatory synaptic vesicle endocytosis in vivo," Nature (London) 426 (2003) 559 - 563.
Background Reference 2:
Wang, C.T., Lu, J.C., Bai, J.H., Chang, P.Y., Martin, T.F.J., Chapman, E.R. and Jackson, M.B. "Different domains of synaptotagmin control the choice between kiss-and-run and full fusion," Nature (London) 424 (2003) 943 - 947.
Background Reference 3:
Fernandez-Chacon, R., Konigstorfer, A., Gerber, S.H., Garcia, J., Matos, M.F., Stevens, C.F., Brose, N., Rizo, J., Rosenmund, C. and Sudhof, T.C., "Synaptotagmin I functions as a calcium regulator of release probability," Nature (London ) 410 (2001) 41 - 49.
Background Reference 4:
Hilfiker, S., Pieribone, V.A., Nordstedt, C., Greengard, P., and Czernik, A.J., "Regulation of synaptotagmin I phosphorylation by multiple protein kinases," J. Neurochem. 73 (1999) 921 - 932.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

XPS-1027

List Size:
0.1 mL

List Price:

$540.00

Datasheet
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