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Western blot analysis in mouse spleen cell line lysates (35ug/lane).
SYNE3 antibody immunohistochemistry analysis in formalin fixed and paraffin embedded human hodgkin lymphoma followed by peroxidase conjugation of the secondary antibody and DAB staining.
Western blot analysis in mouse spleen cell line lysates (35ug/lane).

SYNE3 Antibody

CATALOG NUMBER: 55-447

Clonality:
Polyclonal
Tested Applications:
IHC-P, WB
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Conjugate:
Unconjugated
Specifications
Host Species:
Rabbit
Species Reactivity:
Human, Mouse
Immunogen:
This SYNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 852-880 amino acids from the C-terminal region of human SYNE3.
Conjugate:
Unconjugated
Tested Applications:
IHC-P, WB
Application Note:
For WB starting dilution is: 1:1000
For IHC-P starting dilution is: 1:50~100
Predicted Molecular Weight:
112 kDa
Purification:
This antibody is purified through a protein A column, followed by peptide affinity purification.
Clonality:
Polyclonal
Isotype:
Rabbit Ig
Physical State:
Liquid
Buffer:
Supplied in PBS with 0.09% (W/V) sodium azide.
Concentration:
batch dependent
Storage Conditions:
Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Ncbi Official Symbol:
SYNE3
Additional Names:
Nesprin-3, Nuclear envelope spectrin repeat protein 3, SYNE3, C14orf49
Protein Accession Number:
Q6ZMZ3
Protein Gi Number:
134035037
Ncbi Gene Id Number:
161176
User Note:
Optimal dilutions for each application to be determined by the researcher.
Background:
Component of SUN-protein-containing multivariate complexes also called LINC complexes which link the nucleoskeleton and cytoskeleton by providing versatile outer nuclear membrane attachment sites for cytoskeletal filaments. Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system.
Background Reference 1:
Nery, F.C., et al. J. Cell. Sci. 121 (PT 20), 3476-3486 (2008) :
Background Reference 2:
Stewart-Hutchinson, P.J., et al. Exp. Cell Res. 314(8):1892-1905(2008)
Background Reference 3:
Wilhelmsen, K., et al. J. Cell Biol. 171(5):799-810(2005)
Background Reference 4:
Heilig, R., et al. Nature 421(6923):601-607(2003)

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
Optimal dilutions/concentrations should be determined by the end user. The information provided is a guideline for product use. This product is for research use only.

CATALOG NUMBER:

55-447

List Size:
400 ul

List Price:

$495.00

Datasheet
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