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TACI Recombinant Protein

CATALOG NUMBER: 40-308

Specifications
source-species:
E. coli
Species:
Human
source-species:
E. coli
Recombinant Protein Sequence:
MSGLGRSRRG GRSRVDQEER FPQGLWTGVA MRSCPEEQYW DPLLGTCMSC KTICNHQSQR TCAAFCRSLS CRKEQGKFYD HLLRDCISCA SICGQHPKQC AYFCENKLRS PVNLPPELRR QRSGEVENNS DNSGRYQGLE HRGSEASPAL PGLKLSADQV
Biological Activity:
Biological activity was determined by its ability to block human BAFF induced T2B cell survival using a concentration range of 1.0 - 3.0 μg/mL.
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin level is less than 0.1 ng per μg (1EU/μg).
physical-state:
Lyophilized
Storage Conditions:
The lyophilized TACI recombinant protein is stable for at least 2 years from date of receipt at -20°C. Reconstituted TACI is stable for at least 3 months when stored in working aliquots with a carrier protein at -20°C. As with any protein, exposing TACI recombinant protein to repeated freeze / thaw cycles is not recommended. When working with proteins care should be taken to keep recombinant protein at a cool and stable temperature.
Ncbi Official Symbol:
TNFRSF13B
Additional Names:
CVID, RYZN, TACI, CD267, CVID2, TNFRSF14B, Tumor necrosis factor receptor superfamily member 13B, Transmembrane activator and CAML interactor
Protein Accession Number:
NP_036584.1
Protein Gi Number:
6912694
Ncbi Gene Id Number:
23495
Background:
TACI, a member of the TNF Receptor superfamily, is expressed in the small intestine, spleen, thymus, peripheral blood leukocytes, activated T cells, and resting B cells. TACI binds to both APRIL and BAFF and can stimulate the activation of transcription factors; NF-kappaB, AP-1, and mediates calcineurin dependent activation of NF-AT (nuclear-factor of activated T cells). TACI also plays a key role in the stimulation of B and T cell function. Soluble TACI inhibits APRIL-stimulated proliferation of primary B-cells by blocking the binding of APRIL to the membrane anchored TACI receptor. Recombinant human TACI is a soluble 160 amino acid polypeptide (17.8 kDa) comprising the TNFR homologous cysteine rich extracellular domain of the TACI protein.

FOR RESEARCH USE ONLY

For additional information, visit ProSci’s Terms & Conditions Page.

Disclaimer:
This product is for research use only.

CATALOG NUMBER:

40-308

List Size:
0.005 mg, 0.02 mg

List Price:

Price range: $199.00 through $305.00

Datasheet
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